微信公众号

官网二维码
中国癌症防治杂志

中国癌症防治杂志 ›› 2012, Vol. 4 ›› Issue (2): 184-187.doi: 10.3969/j.issn.1674-5671.2012.02.21

• 基础研究 • 上一篇    下一篇

血管内皮生长因子和促红细胞生成素在单肺通气期间的表达及意义

  

  1. 广西医科大学附属肿瘤医院麻醉科
  • 出版日期:2012-06-25 发布日期:2012-07-03
  • 通讯作者: 潘灵辉 E-mail:plinghui@yahoo.com.cn
  • 基金资助:

    广西自然科学基金资助项目（桂科自 0991235）；广西医疗卫生重点科研课题资助项目（重2010070）

Expression and functional of VEGF and EPO in hypoxic metabolism during one-lung ven-tilation

  • Online:2012-06-25 Published:2012-07-03

PDF (PC)

420

赞

被引次数

1

摘要： 目的 探讨血管内皮生长因子（VEGF）和促红细胞生成素（EPO）在单肺通气（OLV）肺泡细胞低氧代谢的表达及其意义。方法 37例行开胸食管癌手术患者随机分为单肺通气组（OLV组）17例，双肺通气组（TLV组）20例。每组患者分别于OLV或TLV前（T1）、OLV或TLV后30 min（T2）、60 min（T3）、90 min（T4）、120 min（T5）、手术结束时（T6）抽取静脉血，检测血清VEGF、EPO水平；并分别于T1、T3、T6时点行血气分析，监测血红蛋白（HGB）水平。结果 OLV组T6时点PaO2值明显低于TLV组（P＜0.05），除T1、T2外，OLV组各时点VEGF浓度均高于TLV组（P＜0.05），OLV组T5、T6时点的血清EPO浓度明显高于TLV组（P＜0.05）。结论 在单肺通气期间VEGF和EPO因子表达明显上调，可能参与肺组织损伤及修复过程。

关键词: 单肺通气, 食管癌, 血管内皮生长因子, 促红细胞生成素

Abstract: Objective To explore the expression and functional of the serum vascular endothelial growth factor（VEGF） and erythro-poietin（EPO）in hypoxic metabolism during one-lung ventilation（OLV）. Methods Patients undergoing intrathoracic radical resection of esophageal carcinoma were randomly divided into two groups：one in which patients underwent OLV（n = 17）and another in which pa-tients underwent two-lung ventilation（TLV；n = 20）.Blood samples were taken immediately before OLV/TLV（T1） and at 30 min（T2），60 min（T3），90 min（T4） and 120 min（T5） after the start of OLV/TLV.Venous blood was collected at the end of the surgery （T6） to measure expression levels of VEGF and EPO.HGB levels were assessed at T1，T3 and T6. Results PaO2 at T6 was significantly lower in the OLV group than in the TLV group（P＜0.05）.The OLV group showed significantly higher VEGF expression at T3，T4，T5 and T6，as well as significantly higher serum EPO expression at T4 and T5 than did the TLV group（P＜0.05）. Conclusion Expression of VEGF and EPO significantly increased during OLV，suggesting that they participate in the injury and/or healing of pulmonary tis-sue during hypoxia.

Key words: One-lung ventilation, Esophageal carcinoma, Vascular endothelial growth factor , Erythropoietin